African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have exa...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is k...