We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance.The effects of EPO on VEGF expression were studied in cultured cardiac cells and EPO-treated hearts. The role of VEGF in EPO-induced neovascularization was studied with two distinct VEGF-neutralizing antibodies or irrelevant control IgG in an aortic sprouting assay and in rats with heart failure (HF) after myocardial infarction (MI) treated with EPO. EPO-alfa (10 IU/mL) was used in vitro and darbepoetin alfa (40 mu g/kg/3 weeks, starting 3 weeks after MI) in vivo. EPO stimulated VEGF mRNA expression through the signal transd...
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoie...
Anticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), can indu...
EPO (erythropoietin) has long been identified as a primary regulator of erythropoiesis. Subsequently...
We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial...
Aims Erythropoietin (EPO) improves cardiac function and induces neovascutarization in chronic heart ...
Background: Transplantation of marrow stromal cells (MSC) has been shown to improve heart perfusion ...
Background: Erythropoietin (EPO) may improve cardiac function and induce neovascularisation in exper...
Recent studies show that erythropoietin (EPO) plays a protective role in brain ischemia. In this con...
Purpose We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulati...
OBJECTIVES We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-myocardi...
ObjectivesWe assessed the effects of erythropoietin (EPO) treatment in a rat model of post-myocardia...
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoie...
Several studies showed that anaemia is commonly observed in patients with Chronic Heart Failure (CHF...
SummaryAnticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), c...
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoie...
Anticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), can indu...
EPO (erythropoietin) has long been identified as a primary regulator of erythropoiesis. Subsequently...
We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial...
Aims Erythropoietin (EPO) improves cardiac function and induces neovascutarization in chronic heart ...
Background: Transplantation of marrow stromal cells (MSC) has been shown to improve heart perfusion ...
Background: Erythropoietin (EPO) may improve cardiac function and induce neovascularisation in exper...
Recent studies show that erythropoietin (EPO) plays a protective role in brain ischemia. In this con...
Purpose We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulati...
OBJECTIVES We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-myocardi...
ObjectivesWe assessed the effects of erythropoietin (EPO) treatment in a rat model of post-myocardia...
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoie...
Several studies showed that anaemia is commonly observed in patients with Chronic Heart Failure (CHF...
SummaryAnticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), c...
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoie...
Anticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), can indu...
EPO (erythropoietin) has long been identified as a primary regulator of erythropoiesis. Subsequently...