Asymmetric Hydrogenation of Quinoxalines Catalyzed by Iridium/PipPhos
- Mrsic, Natasa
- Jerphagnon, Thomas
- Minnaard, Adriaan J.
- Feringa, Ben L.
- de Vries, Johannes G.
DOIAbstract
A catalyst made in situ from the (cyclooctadiene)iridium chloride dimer, [Ir(COD)Cl](2), and the monodentate phosphoramidite ligand (S)-PipPhos was used in the enantioselective hydrogenation of 2- and 2,6-substituted quinoxalines. In the presence of piperidine hydrochloride as additive full conversions and enantioselectivities of up to 96% are obtained.</p
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