The association of HDL cholesterol concentration with the-629C > A CETP promoter polymorphism is not fully explained by its relationship with plasma cholesteryl ester transfer

Objective . HDL cholesterol is associated with the -629C>A cholesteryl ester transfer protein (CETP) promoter polymorphism. This relationship may in part be explained via effects on plasma cholesteryl ester transfer (CET), which reflects the activity of CETP in the context of endogenous lipoproteins, but also via CET independent pathways involved in HDL metabolism. In this study, we determined the contributions of the CETP -629C>A genotype, plasma CETP mass and cholesteryl ester transfer to HDL cholesterol. Material and methods . The -629 C>A CETP gene promoter polymorphism, plasma CETP mass, CET, HDL cholesterol, lipids and apolipoprotein (apo) A-I were measured in 220 non-diabetic men without cardiovascular disease. Results . Plasma CETP mass (p