Background and purpose: It has been proposed that radiation induced stimulation of ATM and downstream components involves activation of TGF beta-1 and that this may be due to TGF beta-1-receptor I-Smad signalling. Therefore, the aim of this study was to clarify the distinct role of TGF beta-1-receptor I-Smad signalling in mediating ATM activity following radiation exposure.Materials and methods: A549 cells were stably transfected with a conditionally regulatable TGF beta-1 antisense construct (Tet-on-system) to test clonogenic activity following irradiation. Phosphorylation profile of ATM, p53, and chk2 was determined in non-cycling, serum-starved cells by immunoblotting. Likewise, A549 wild type cells were used to identify cell cycle distr...
The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular p...
TGF-β signaling regulates several different biological processes involving cell-growth, differentiat...
Emerging evidences show that changes in tumor stroma can adapt cancer cells to radiotherapy, thereby...
Background and purpose: It has been proposed that radiation induced stimulation of ATM and downstrea...
Ionizing radiation causes DNA damage that elicits a cellular program of damage control coordinated b...
Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergist...
Radiation-induced fibrosis is an important side effect in the treatment of cancer. Profibrotic prote...
Background: Ataxia-telangiectasia is a pleiotropic autosomal recessive disorder caused by mutations ...
Epidermal growth factor (EGF) has been reported to either sensitize or protect cells against ionizin...
Item does not contain fulltextRadiation-induced fibrosis is an important side effect in the treatmen...
Ataxia telangiectasia-mutated (ATM) is a serine/threonine protein kinase that has critical functions...
From our ongoing in vitro studies using the Fisher Rat Thyroid cell line-5 (FRTL-5) we recorded acce...
Epidermal growth factor (EGF) has been reported to either sensitize or protect cells against ionizin...
Purpose: The product of the gene ATM mutated in the human genetic disorder ataxia-telangiectasia (A-...
Glioblastoma multiforme (GBM) is the most common primary brain tumor. Studies have shown that targe...
The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular p...
TGF-β signaling regulates several different biological processes involving cell-growth, differentiat...
Emerging evidences show that changes in tumor stroma can adapt cancer cells to radiotherapy, thereby...
Background and purpose: It has been proposed that radiation induced stimulation of ATM and downstrea...
Ionizing radiation causes DNA damage that elicits a cellular program of damage control coordinated b...
Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergist...
Radiation-induced fibrosis is an important side effect in the treatment of cancer. Profibrotic prote...
Background: Ataxia-telangiectasia is a pleiotropic autosomal recessive disorder caused by mutations ...
Epidermal growth factor (EGF) has been reported to either sensitize or protect cells against ionizin...
Item does not contain fulltextRadiation-induced fibrosis is an important side effect in the treatmen...
Ataxia telangiectasia-mutated (ATM) is a serine/threonine protein kinase that has critical functions...
From our ongoing in vitro studies using the Fisher Rat Thyroid cell line-5 (FRTL-5) we recorded acce...
Epidermal growth factor (EGF) has been reported to either sensitize or protect cells against ionizin...
Purpose: The product of the gene ATM mutated in the human genetic disorder ataxia-telangiectasia (A-...
Glioblastoma multiforme (GBM) is the most common primary brain tumor. Studies have shown that targe...
The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular p...
TGF-β signaling regulates several different biological processes involving cell-growth, differentiat...
Emerging evidences show that changes in tumor stroma can adapt cancer cells to radiotherapy, thereby...