Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpression in tumorsis considered a predictor of more advanced stage disease and of worse prognosis in a number of studies investigating solid malignancies. Therefore, NSAIDs are evaluated as anti-cancer drugs. NSAIDs inhibit proliferation, invasiveness of tumors, and angiogenesis and overcome apoptosis resistance in a COX-2 dependent and independent manner. This review will focus on the rationale behind NSAIDs, including selective COX-2 inhibitors, in combination with conventional chemotherapeutic drugs or novel molecular targeted drugs. Studies investigating anti-cancer effects of NSAIDs on cell lines and xenograft models have shown modulation of...
Cyclooxygenase-2 (COX-2) is frequently expressed in many types of cancers exerting a pleiotropic and...
Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incide...
Abstract. Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. Nonse...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, ar...
Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incide...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of prostaglandins. Very ...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Non-steroidal anti-inflammatory drugs (NSAIDs) including cyclooxygenase 2 (COX-2) selective inhibito...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2...
Cyclooxygenase-2 (COX-2) is frequently expressed in many types of cancers exerting a pleiotropic and...
Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incide...
Abstract. Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. Nonse...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpres...
Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, ar...
Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incide...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of prostaglandins. Very ...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Non-steroidal anti-inflammatory drugs (NSAIDs) including cyclooxygenase 2 (COX-2) selective inhibito...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2...
Cyclooxygenase-2 (COX-2) is frequently expressed in many types of cancers exerting a pleiotropic and...
Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incide...
Abstract. Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. Nonse...