Atypical antipsychotic-like effects of the dopamine D-3 receptor agonist, (+)-PD 128,907

Anti-schizophrenia agents with improved efficacy and side-effect profiles are required. A dopamine D-3 receptor agonist, R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol HCl ((+)-PD 128,907), displayed an atypical antipsychotic profile comparable to that of clozapine. (+)-PD 128,907 blocked stereotypy produced by dizocilpine (MK-801) at 12-fold lower doses than those affecting apomorphine-induced stereotypes in mice and did not produce catalepsy. These effects of(+)-PD 128,907 were stereospecific and were blocked by a D-3 antagonist. These data suggest a role for D-3 receptors in antipsychotic drug action. Published by Elsevier Science B.V.