Adenosarcoma of the uterus following tamoxifen treatment for breast cancer

A 71-year-old patient developed an uterine adenosarcoma two months after two years of tamoxifen adjuvant treatment for early breast cancer. After curettage for postmenopausal bleeding, the patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Histologic examination revealed an adenosarcoma of the uterus without myometrial invasion or lymphatic spread. After four years of follow-up, there was no evidence of recurrent disease. The possible association between tamoxifen treatment and uterine sarcoma is discussed.