Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands

Mrsic, Natasa
Panella, Lavinia
Minnaard, Adriaan J.
Feringa, Ben L.
de Vries, Johannes G.

Publication date

January 2011

DOI

10.1016/j.tetasy.2010.11.026

Abstract

The iridium-catalyzed asymmetric hydrogenation of N-phenyl-beta-dehydroamino acid derivatives was examined using monodentate phosphoramidite ligands. The highest yields and enantioselectivities were obtained using a mixed ligand approach with PipPhos L1 and achiral triphenylphosphine (full conversion, 70% ee). (C) 2010 Elsevier Ltd. All rights reserved.</p

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Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands

Abstract

Extracted data

Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands

Abstract

Extracted data

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