Unravelling the proteome of diffuse large B-cell lymphoma:Differences in cell of origin and HLA loss

The DLBCL microenvironment: A proteomics approach to identify novel players involved in the tumor cell - microenvironment interactions.Diffuse large B-cell lymphoma (DLBCL) can present de novo or transform from a less aggressive lymphoma. The pathogenesis of DLBCL is a multistep process that involves genetic alterations, immune status of the patient and tumour microenvironment. The Human Leukocyte Antigen (HLA) system regulates the immune response and loss of HLA expression in the tumour cells leads to an altered host immunity and impairs effective anti-tumour responses. Our aim is to investigate the proteome of tumor cells to identify proteins that play a role in the cross talk between tumor cells and the microenvironment in DLBCL. The ultimate goal is to explain why patients react differently to therapy and to provide a tailored treatment plan in order to avoid over- and undertreatment