Diet and physical activity are thought to affect sustainable metabolic health and survival. To improve understanding, we studied survival of mice feeding a low-fat (LF) or high-saturated fat/high sugar (HFS) diet, each with or without free running wheel (RW) access. Additionally several endocrine and metabolic health indices were assessed at 6, 12, 18 and 24 months of age. As expected, HFS feeding left-shifted survival curve of mice compared to LF feeding, and this was associated with increased energy intake and increased (visceral/total) adiposity, liver triglycerides, and increased plasma cholesterol, corticosterone, HOMA-IR, and lowered adiponectin levels. Several of these health parameters improved (transiently) by RW access in HFS and ...
Inflammatory bowel disease (IBD) is a chronic, inflammatory disorder of the gastrointestinal tract, ...
Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health an...
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β (TGFβ) supe...
Diet and physical activity are thought to affect sustainable metabolic health and survival. To impro...
During the course of evolution, up until the agricultural revolution, environmental fluctuations for...
The aging process is associated with the development of several chronic diseases. White adipose tiss...
Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-in...
Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preve...
Increasing age is a risk factor for many diseases; therefore developing pharmacological intervention...
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylat...
Major scholars in the field, based on a 3-day consensus, created an in-depth review of current knowl...
This dissertation studied the relationship between incretins, a new group of blood glucose lowering ...
The number of people affected by type 2 diabetes (i.e. high blood glucose levels) is increasing rapi...
Despite a number of biochemical and lifestyle differences which should increase risk of oxidative da...
While much research has focused on the costs of obesity and economic factors that drive obesity grow...
Inflammatory bowel disease (IBD) is a chronic, inflammatory disorder of the gastrointestinal tract, ...
Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health an...
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β (TGFβ) supe...
Diet and physical activity are thought to affect sustainable metabolic health and survival. To impro...
During the course of evolution, up until the agricultural revolution, environmental fluctuations for...
The aging process is associated with the development of several chronic diseases. White adipose tiss...
Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-in...
Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preve...
Increasing age is a risk factor for many diseases; therefore developing pharmacological intervention...
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylat...
Major scholars in the field, based on a 3-day consensus, created an in-depth review of current knowl...
This dissertation studied the relationship between incretins, a new group of blood glucose lowering ...
The number of people affected by type 2 diabetes (i.e. high blood glucose levels) is increasing rapi...
Despite a number of biochemical and lifestyle differences which should increase risk of oxidative da...
While much research has focused on the costs of obesity and economic factors that drive obesity grow...
Inflammatory bowel disease (IBD) is a chronic, inflammatory disorder of the gastrointestinal tract, ...
Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health an...
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β (TGFβ) supe...