The mechanisms of cardiovascular and renal protection observed in clinical trials of SGLT2 inhibitors (SGLT2i) are incompletely understood and likely multifactorial, including natriuretic, diuretic, and antihypertensive effects, glomerular pressure reduction, and lowering of plasma and interstitial fluid volume. To quantitatively evaluate the contribution of proposed SGLT2i mechanisms of action on changes in renal hemodynamics and volume status, we coupled a mathematical model of renal function and volume homeostasis with clinical data in healthy subjects administered 10 mg dapagliflozin once-daily. The minimum set of mechanisms necessary to reproduce observed clinical responses (urinary sodium and water excretion, serum creatinine and sodi...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canag...
SGLT2 inhibitor, a kind of hypoglycemic drug, whose mechanism is to suppress glucose reabsorption in...
The kidney has a prominent role in maintaining glucose homeostasis by using glucose as a metabolic s...
The mechanisms of cardiovascular and renal protection observed in clinical trials of SGLT2 inhibitor...
The mechanisms of cardiovascular and renal protection observed in clinical trials of SGLT2 inhibitor...
Sodium glucose cotransporter 2 inhibitors (SGLT2i) reduce cardiovascular events and onset and progre...
SGLT2 inhibitors are antihyperglycemic drugs that protect kidneys and the heart of patients with or ...
Abstract Sodium‐glucose cotransporter (SGLT)‐2 inhibitors have recently been approved for chronic ki...
In individuals with diabetes, kidney size and glomerular filtration rate (GFR) tend to increase, and...
peer reviewedINTRODUCTION: Sodium-glucose co-transporter type 2 inhibitors (SGLT2is) were developed ...
Type 2 diabetes mellitus (T2DM) is a growing public health concern worldwide. Numerous drug classes ...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canag...
Sodium-glucose co-transporter 2 (SGLT2) inhibitors immediately reduce the glomerular filtration rate...
peer reviewedSodium-glucose cotransporter type 2 inhibitors (SGLT2is) are new oral glucose-lowering ...
Sodium-glucose linked transporter 2 (SGLT2) inhibitors are a new and promising class of antidiabetic...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canag...
SGLT2 inhibitor, a kind of hypoglycemic drug, whose mechanism is to suppress glucose reabsorption in...
The kidney has a prominent role in maintaining glucose homeostasis by using glucose as a metabolic s...
The mechanisms of cardiovascular and renal protection observed in clinical trials of SGLT2 inhibitor...
The mechanisms of cardiovascular and renal protection observed in clinical trials of SGLT2 inhibitor...
Sodium glucose cotransporter 2 inhibitors (SGLT2i) reduce cardiovascular events and onset and progre...
SGLT2 inhibitors are antihyperglycemic drugs that protect kidneys and the heart of patients with or ...
Abstract Sodium‐glucose cotransporter (SGLT)‐2 inhibitors have recently been approved for chronic ki...
In individuals with diabetes, kidney size and glomerular filtration rate (GFR) tend to increase, and...
peer reviewedINTRODUCTION: Sodium-glucose co-transporter type 2 inhibitors (SGLT2is) were developed ...
Type 2 diabetes mellitus (T2DM) is a growing public health concern worldwide. Numerous drug classes ...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canag...
Sodium-glucose co-transporter 2 (SGLT2) inhibitors immediately reduce the glomerular filtration rate...
peer reviewedSodium-glucose cotransporter type 2 inhibitors (SGLT2is) are new oral glucose-lowering ...
Sodium-glucose linked transporter 2 (SGLT2) inhibitors are a new and promising class of antidiabetic...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canag...
SGLT2 inhibitor, a kind of hypoglycemic drug, whose mechanism is to suppress glucose reabsorption in...
The kidney has a prominent role in maintaining glucose homeostasis by using glucose as a metabolic s...