BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptimal donor livers prior to implantation. Our aim was to assess the diagnostic accuracy of bile biochemistry for the assessment of bile duct injury (BDI).METHODS: In a preclinical study, 23 human donor livers underwent 6 hours of end-ischemic NMP to determine biomarkers of BDI. Livers were divided into groups with low or high BDI, based on a clinically relevant histological grading system. During NMP, bile was analyzed biochemically and potential biomarkers were correlated with the degree of BDI. Receiver operating characteristics curves were generated to determine optimal cut-off values. For clinical validation, identified biomarkers were subse...
Machine perfusion of human donor livers offers the possibility to protect organs against damage and ...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
There currently is a shortage of suitable donor livers in the Netherlands. In 2016, waiting list mor...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Machine perfusion of human donor livers offers the possibility to protect organs against damage and ...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
There currently is a shortage of suitable donor livers in the Netherlands. In 2016, waiting list mor...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: Ex situ normothermic machine perfusion (NMP) can be used to assess viability of suboptim...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
BACKGROUND: End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor li...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
Machine perfusion of human donor livers offers the possibility to protect organs against damage and ...
Although normothermic machine perfusion of donor livers may allow assessment of graft viability prio...
There currently is a shortage of suitable donor livers in the Netherlands. In 2016, waiting list mor...