SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are mutated across many cancer types. The highest mutation incidence is found in ARID1A, primarily consisting of deleterious mutations. Current advances have reported synthetic lethal interactions with the loss of ARID1A in several cancer types. In this review, we discuss targets that are only important for tumor growth in an ARID1A mutant context. We focus on synthetic lethal strategies with ARID1A loss in ovarian clear cell carcinoma, a cancer...
ABSTRACT ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identifi ed tumor suppr...
SWI/SNF chromatin remodelling complex has been described to be altered in nearly 20 % of all human t...
The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a d...
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chroma...
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chroma...
© 2015 © 2015 Taylor & Francis. ARID1A is a subunit of the Switch/Sucrose Non-Fermentable (SWI/SNF) ...
Current treatment for advanced stage ovarian clear cell cancer is severely hampered by a lack of eff...
Summary: ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across...
ARID1A belongs to a class of chromatin regulatory proteins that function by maintaining accessibilit...
AT-rich interactive domain 1A (ARID1A) and AT-rich interactive domain 1B (ARID1B) are subunits of th...
Ovarian clear cell carcinoma (OCCC) is a histological subtype of ovarian cancer that is more frequen...
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Defi...
ABSTRACT ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identifi ed tumor suppr...
SWI/SNF chromatin remodelling complex has been described to be altered in nearly 20 % of all human t...
The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a d...
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chroma...
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chroma...
© 2015 © 2015 Taylor & Francis. ARID1A is a subunit of the Switch/Sucrose Non-Fermentable (SWI/SNF) ...
Current treatment for advanced stage ovarian clear cell cancer is severely hampered by a lack of eff...
Summary: ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across...
ARID1A belongs to a class of chromatin regulatory proteins that function by maintaining accessibilit...
AT-rich interactive domain 1A (ARID1A) and AT-rich interactive domain 1B (ARID1B) are subunits of th...
Ovarian clear cell carcinoma (OCCC) is a histological subtype of ovarian cancer that is more frequen...
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Defi...
ABSTRACT ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identifi ed tumor suppr...
SWI/SNF chromatin remodelling complex has been described to be altered in nearly 20 % of all human t...
The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a d...