Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

Open PDF

Open link

Publication date

July 2017

DOI

10.1186/s12905-017-0378-y

Language

English

Abstract

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle.Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom ha...

Extracted data

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Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

Open PDF

Open link

Publication date

July 2017

DOI

10.1186/s12905-017-0378-y

Language

English

Abstract

Extracted data

van Hoogenhuijze, N E
Mol, F
Laven, J S E
Groenewoud, E R
Traas, M A F
Janssen, C A H
Teklenburg, G
de Bruin, J P
van Oppenraaij, R H F
Maas, J W M
Moll, E
Fleischer, K
van Hooff, M H A
de Koning, C H
Cantineau, A E P
Lambalk, C B
Verberg, M
van Heusden, A M
Manger, A P
van Rumste, M M E
van der Voet, L F
Pieterse, Q D
Visser, J
Brinkhuis, E A
den Hartog, J E
Glas, M W
Klijn, N F
van der Meer, S
Bandell, M L
Boxmeer, J C
van Disseldorp, J
Smeenk, J
van Wely, M
Eijkemans, M J C
Torrance, H L
Broekmans, F J M

January 2021

STUDY QUESTION: Does endometrial scratching in women with one failed IVF/ICSI treatment affect the c...

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C.
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

May 2018

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

January 2018

Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy ra...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S.E.
Scheenjes, E.
Traas, M. A.F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W.M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J.C.
Kasius, J. C.
Broekmans, F. J.M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study : A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, Joop S E
Scheenjes, E.
Traas, M.A.F.
Janssen, Bert J C
Cohlen, B.
Teklenburg, G.
Bruin, Jacob P
van Oppenraaij, R.
Maas, J. W M
Moll, Etelka
Fleischer, K.
van Hooff, Marcel H
de Koning, C.
Cantineau, A.
Lambalk, Cornelis B.
Verberg, M.F.G.
Nijs, M. M.
Manger, A. P.
Van Rumste, M. M.
Van der Voet, L F
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.A.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
Wely, M.
Smeenk, J.
Pieterse, Q.D.
Boxmeer, J.C.
Groenewoud, Eva R.
Eijkemans, M. J.C.
Kasius, J. C.
Broekmans, F. J.M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)

Hoogenhuijze, N.E. van
Torrance, H.L.
Mol, F.
Laven, J.S.
Scheenjes, E.
Traas, M.A.F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
Bruin, J.P. de
Oppenraaij, R. van
Maas, J.W.
Moll, E.
Fleischer, K.
Hooff, M.H. van
Koning, C.
Cantineau, A.
Lambalk, C.B.
Verberg, M.
Nijs, M.
Manger, A.P.
Rumste, M. van
Voet, L.F. van der
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
Hartog, J.E. Den
Sluijmer, A.
Jansen, F.W.
Hermes, W.
Bandell, M.L.
Pelinck, M.J.
Disseldorp, J. van
Wely, M. van
Smeenk, J.
Pieterse, Q.D.
Boxmeer, J.C.
Groenewoud, E.R.
Eijkemans, M.J.
Kasius, J.C.
Broekmans, F.J.

January 2017

BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:a randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)? Study protocol of the SCRaTCH-OFO trial:a randomized controlled trial

Bui, B. N.
Torrance, H. L.
Janssen, C.
Cohlen, B.
de Bruin, J. P.
den Hartog, J. E.
van der Linden, P. J. Q.
Deurloo, K. L.
Maas, J. W. M.
van Oppenraaij, R.
Cantineau, A.
Lambalk, C. B.
Visser, H.
Brinkhuis, E.
van Disseldorp, J.
Schoot, B. C.
Lardenoije, C.
van Wely, M.
Eijkemans, M. J. C.
Broekmans, F. J. M.

December 2018

BackgroundIn the Netherlands, couples with unexplained infertility and a good prognosis to conceive ...

Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH)

van Hoogenhuijze, N E
Mol, F
Laven, J S E
Groenewoud, E R
Traas, M A F
Janssen, C A H
Teklenburg, G
de Bruin, J P
van Oppenraaij, R H F
Maas, J W M
Moll, E
Fleischer, K
van Hooff, M H A
de Koning, C H
Cantineau, A E P
Lambalk, C B
Verberg, M
van Heusden, A M
Manger, A P
van Rumste, M M E
van der Voet, L F
Pieterse, Q D
Visser, J
Brinkhuis, E A
den Hartog, J E
Glas, M W
Klijn, N F
van der Meer, S
Bandell, M L
Boxmeer, J C
van Disseldorp, J
Smeenk, J
van Wely, M
Eijkemans, M J C
Torrance, H L
Broekmans, F J M

January 2021

STUDY QUESTION: Does endometrial scratching in women with one failed IVF/ICSI treatment affect the c...

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C.
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

May 2018

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

January 2018

Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy ra...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S.E.
Scheenjes, E.
Traas, M. A.F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W.M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J.C.
Kasius, J. C.
Broekmans, F. J.M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study : A randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, Joop S E
Scheenjes, E.
Traas, M.A.F.
Janssen, Bert J C
Cohlen, B.
Teklenburg, G.
Bruin, Jacob P
van Oppenraaij, R.
Maas, J. W M
Moll, Etelka
Fleischer, K.
van Hooff, Marcel H
de Koning, C.
Cantineau, A.
Lambalk, Cornelis B.
Verberg, M.F.G.
Nijs, M. M.
Manger, A. P.
Van Rumste, M. M.
Van der Voet, L F
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.A.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
Wely, M.
Smeenk, J.
Pieterse, Q.D.
Boxmeer, J.C.
Groenewoud, Eva R.
Eijkemans, M. J.C.
Kasius, J. C.
Broekmans, F. J.M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)

Hoogenhuijze, N.E. van
Torrance, H.L.
Mol, F.
Laven, J.S.
Scheenjes, E.
Traas, M.A.F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
Bruin, J.P. de
Oppenraaij, R. van
Maas, J.W.
Moll, E.
Fleischer, K.
Hooff, M.H. van
Koning, C.
Cantineau, A.
Lambalk, C.B.
Verberg, M.
Nijs, M.
Manger, A.P.
Rumste, M. van
Voet, L.F. van der
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
Hartog, J.E. Den
Sluijmer, A.
Jansen, F.W.
Hermes, W.
Bandell, M.L.
Pelinck, M.J.
Disseldorp, J. van
Wely, M. van
Smeenk, J.
Pieterse, Q.D.
Boxmeer, J.C.
Groenewoud, E.R.
Eijkemans, M.J.
Kasius, J.C.
Broekmans, F.J.

January 2017

BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:a randomized controlled trial (NTR 5342)

van Hoogenhuijze, N. E.
Torrance, H. L.
Mol, F.
Laven, J. S. E.
Scheenjes, E.
Traas, M. A. F.
Janssen, C.
Cohlen, B.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R.
Maas, J. W. M.
Moll, E.
Fleischer, K.
van Hooff, M. H.
de Koning, C.
Cantineau, A.
Lambalk, C. B.
Verberg, M.
Nijs, M.
Manger, A. P.
van Rumste, M.
van der Voet, L. F.
Preys-Bosman, A.
Visser, J.
Brinkhuis, E.
den Hartog, J. E.
Sluijmer, A.
Jansen, F. W.
Hermes, W.
Bandell, M. L.
Pelinck, M. J.
van Disseldorp, J.
van Wely, M.
Smeenk, J.
Pieterse, Q. D.
Boxmeer, J. C.
Groenewoud, E. R.
Eijkemans, M. J. C.
Kasius, J. C.
Broekmans, F. J. M.

July 2017

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the ...

Bui, B. N.
Torrance, H. L.
Janssen, C.
Cohlen, B.
de Bruin, J. P.
den Hartog, J. E.
van der Linden, P. J. Q.
Deurloo, K. L.
Maas, J. W. M.
van Oppenraaij, R.
Cantineau, A.
Lambalk, C. B.
Visser, H.
Brinkhuis, E.
van Disseldorp, J.
Schoot, B. C.
Lardenoije, C.
van Wely, M.
Eijkemans, M. J. C.
Broekmans, F. J. M.

December 2018

BackgroundIn the Netherlands, couples with unexplained infertility and a good prognosis to conceive ...

Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH)

van Hoogenhuijze, N E
Mol, F
Laven, J S E
Groenewoud, E R
Traas, M A F
Janssen, C A H
Teklenburg, G
de Bruin, J P
van Oppenraaij, R H F
Maas, J W M
Moll, E
Fleischer, K
van Hooff, M H A
de Koning, C H
Cantineau, A E P
Lambalk, C B
Verberg, M
van Heusden, A M
Manger, A P
van Rumste, M M E
van der Voet, L F
Pieterse, Q D
Visser, J
Brinkhuis, E A
den Hartog, J E
Glas, M W
Klijn, N F
van der Meer, S
Bandell, M L
Boxmeer, J C
van Disseldorp, J
Smeenk, J
van Wely, M
Eijkemans, M J C
Torrance, H L
Broekmans, F J M

January 2021

STUDY QUESTION: Does endometrial scratching in women with one failed IVF/ICSI treatment affect the c...

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: Study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C.
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

May 2018

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial

Pye, Clare
Chatters, Robin
Cohen, Judith
Brian, Kate
Cheong, Ying C
Laird, Susan
Mohiyiddeen, Lamiya
Skull, Jonathan
Walters, Stephen
Young, Tracey
Metwally, Mostafa

January 2018

Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy ra...

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

Abstract

Extracted data

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study:A randomized controlled trial (NTR 5342)

Abstract

Extracted data

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