Metalloproteases, notably members of the matrix metalloprotease (MMP) and A Disintegrin And Metalloprotease (ADAM) families play crucial roles in tissue remodeling, the liberation of growth factors and cytokines from cell membranes (shedding) and cell-cell or cell-matrix interactions. Activity of MMPs or ADAMs must therefore be tightly controlled in time and space by activation of pro-enzymes upon appropriate stimuli and inhibition by endogenous tissue inhibitors of metalloproteases (TIMPs) or α2-macroglobulin to prevent irreversible tissue damage due to excessive degradation or uncontrolled release of potent inflammatory mediators, such as tumor necrosis factor-α (TNF-α).Although there is a wide range of methods to measure the amount of me...
Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases. Identification ...
Matrix metalloproteinases (MMPs) are zinc dependent metalloproteases characterized by the ability to...
International audienceThe first matrix metalloproteinase (MMP) was discovered in 1962 from the tail ...
Metalloproteases, notably members of the matrix metalloprotease (MMP) and A Disintegrin And Metallop...
Metalloproteases (ADAMs, MMPs) are multidomain proteins that play key roles in extracellular matrix ...
International audienceActivity-based probes enable discrimination between the active enzyme and its ...
Le développement d’une nouvelle sonde dite « activity-based probe » pour réaliser la détection de fo...
This thesis describes the design, synthesis and application of chemical tools for the activity-based...
A photoaffinity probe, developed for the specific labeling of matrix metalloproteinase (MMP) active ...
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on ...
Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining ti...
Matrix metalloproteases (MMPs) are secreted or membrane-bound zinc-containing proteases that play di...
Matrix metalloproteinases (MMPs) are a major group of enzymes that regulate cell–matrix composition....
The Matrix Metalloproteinases (MMP) represent a family of Zinc dependent extracellular proteinases a...
Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases w...
Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases. Identification ...
Matrix metalloproteinases (MMPs) are zinc dependent metalloproteases characterized by the ability to...
International audienceThe first matrix metalloproteinase (MMP) was discovered in 1962 from the tail ...
Metalloproteases, notably members of the matrix metalloprotease (MMP) and A Disintegrin And Metallop...
Metalloproteases (ADAMs, MMPs) are multidomain proteins that play key roles in extracellular matrix ...
International audienceActivity-based probes enable discrimination between the active enzyme and its ...
Le développement d’une nouvelle sonde dite « activity-based probe » pour réaliser la détection de fo...
This thesis describes the design, synthesis and application of chemical tools for the activity-based...
A photoaffinity probe, developed for the specific labeling of matrix metalloproteinase (MMP) active ...
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on ...
Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining ti...
Matrix metalloproteases (MMPs) are secreted or membrane-bound zinc-containing proteases that play di...
Matrix metalloproteinases (MMPs) are a major group of enzymes that regulate cell–matrix composition....
The Matrix Metalloproteinases (MMP) represent a family of Zinc dependent extracellular proteinases a...
Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases w...
Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases. Identification ...
Matrix metalloproteinases (MMPs) are zinc dependent metalloproteases characterized by the ability to...
International audienceThe first matrix metalloproteinase (MMP) was discovered in 1962 from the tail ...