Reversibility of pulmonary function after inhaling salbutamol in different doses and body postures in asthmatic children

Rationale: Pulmonary medication is often delivered in the form of medical aerosols designed for inhalation. Recently, breath actuated inhalers (BAI's) gained popularity as they can be used without spacers. A major drawback of BAI's is the impaction in the upper airway. Stretching the upper airway by a forward leaning body posture with the neck extended ("sniffing position") during inhalation may reduce upper airway impaction and improve pulmonary deposition. Aim of this study was to investigate the reversibility of lung function with different doses salbutamol inhaled with a BAI in the forward leaning posture compared to the standard posture in asthmatic children.Methods: 22 clinically stable asthmatic children, 5-14 years old, performed four reversibility measurements. Children inhaled 200 mu g or 400 mu g salbutamol with a BAI in the standard or in the forward leaning posture with the neck extended in a randomized single-blinded cross-over design.Results: Reversibility of lung function after inhaling salbutamol in the forward leaning posture was not significantly different compared to inhalation in the standard posture. Mean FEV1 reversibility was significantly greater after inhaling 400 mu g salbutamol compared to 200 mu g salbutamol in the standard posture (9.4% +/- 9.5% versus 4.5% +/- 7.5%, difference 4.9% (95CI 0.9; 9.0%); p = 0.021).Conclusion: In clinically stable asthmatic children, inhalation of salbutamol with a BAI in a forward leaning posture does not increase reversibility of lung function. Inhalation of 400 mu g compared to 200 mu g salbutamol with a BAI does improve reversibility. (C) 2015 Elsevier Ltd. All rights reserved.