Afg3p and Rca1p are adenosine triphosphate (ATP)-dependent metalloproteases in yeast mitochondria. Cells lacking both proteins exhibit defects in respiration-dependent growth, degradation of mitochondrially synthesized proteins, and assembly of inner-membrane complexes. Defects in growth and protein assembly, but not in degradation, were suppressed by overproduction of yeast mitochondrial Lon, an ATP-dependent serine protease. Suppression by Lon was enhanced by inactivation of the proteolytic site and was prevented by mutation of the ATP-binding site. It is suggested that the mitochondrial proteases Lon, Afg3p, and Rca1p can also serve a chaperone-like function in the assembly of mitochondrial protein complexes.</p
Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron...
AbstractThe AAA+ Lon protease is a soluble single-ringed homo-oligomer, which represents the most st...
Mitochondria are organelles of endosymbiotic origin responsible for many cellular functions, includi...
Afg3p and Rca1p are adenosine triphosphate (ATP)-dependent metalloproteases in yeast mitochondria. C...
The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective pr...
The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective pr...
Regulated protein degradation by ATP-dependent proteases plays a fundamental role in the biogenesis ...
Various adenosine triphosphate (ATP)-dependent proteases were identified within mitochondria which m...
AbstractThe yeast AFG3 gene encodes an ATP-dependent metalloprotease belonging to a subgroup of the ...
Mitochondria are dynamic, semi-autonomous organelles that execute numerous life-sustaining tasks in ...
AbstractProteolytic activity in yeast mitochondrial membranes and soluble fractions was studied usin...
PIM1 protease in mitochondria belongs to a conserved family of ATP-dependent proteases, which includ...
International audience: ATP-dependent proteases are currently emerging as key regulators of mitochon...
The morphology of mitochondria in mammalian cells is regulated by proteolytic cleavage of OPA1, a dy...
The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either...
Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron...
AbstractThe AAA+ Lon protease is a soluble single-ringed homo-oligomer, which represents the most st...
Mitochondria are organelles of endosymbiotic origin responsible for many cellular functions, includi...
Afg3p and Rca1p are adenosine triphosphate (ATP)-dependent metalloproteases in yeast mitochondria. C...
The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective pr...
The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective pr...
Regulated protein degradation by ATP-dependent proteases plays a fundamental role in the biogenesis ...
Various adenosine triphosphate (ATP)-dependent proteases were identified within mitochondria which m...
AbstractThe yeast AFG3 gene encodes an ATP-dependent metalloprotease belonging to a subgroup of the ...
Mitochondria are dynamic, semi-autonomous organelles that execute numerous life-sustaining tasks in ...
AbstractProteolytic activity in yeast mitochondrial membranes and soluble fractions was studied usin...
PIM1 protease in mitochondria belongs to a conserved family of ATP-dependent proteases, which includ...
International audience: ATP-dependent proteases are currently emerging as key regulators of mitochon...
The morphology of mitochondria in mammalian cells is regulated by proteolytic cleavage of OPA1, a dy...
The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either...
Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron...
AbstractThe AAA+ Lon protease is a soluble single-ringed homo-oligomer, which represents the most st...
Mitochondria are organelles of endosymbiotic origin responsible for many cellular functions, includi...