Cell replacement therapy aiming at the compensation of lost oligodendrocytes and restoration of myelination in acquired or congenital demyelination disorders has gained considerable interest since the discovery of induced pluripotent stem cells (iPSCs). Patient-derived iPSCs provide an inexhaustible source for transplantable autologous oligodendrocyte precursors (OPCs). The first transplantation studies in animal models for demyelination with iPSC-derived OPCs demonstrated their survival and remyelinating capacity, but also revealed their limited migration capacity. In the present study, we induced overexpression of the polysialylating enzyme sialyltransferase X (STX) in iPSC-derived OPCs to stimulate the production of polysialic acid-neuro...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeut...
Induced pluripotent stem cell-derived neural precursor cells (iPS-NPCs) may represent the ideal auto...
Cell replacement therapy aiming at the compensation of lost oligodendrocytes and restoration of myel...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
The technology to generate autologous pluripotent stem cells (iPS cells) from almost any somatic cel...
SummaryMultiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects t...
le ra w linating disease of the CNS that is distinguished by recur- of purified OPCs in a relatively...
Damage of myelin is a component of many diseases in the central nervous system (CNS). The activation...
Demyelinating disorders such as leukodystrophies and multiple sclerosis are neurodegenerative diseas...
SummaryNeonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of th...
The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells...
The most challenging aspect of secondary progressive multiple sclerosis (SPMS) is the lack of effici...
© 2015 Dr. Yao Lulu XingRemyelination following demyelination of the central nervous system is media...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeut...
Induced pluripotent stem cell-derived neural precursor cells (iPS-NPCs) may represent the ideal auto...
Cell replacement therapy aiming at the compensation of lost oligodendrocytes and restoration of myel...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
The technology to generate autologous pluripotent stem cells (iPS cells) from almost any somatic cel...
SummaryMultiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects t...
le ra w linating disease of the CNS that is distinguished by recur- of purified OPCs in a relatively...
Damage of myelin is a component of many diseases in the central nervous system (CNS). The activation...
Demyelinating disorders such as leukodystrophies and multiple sclerosis are neurodegenerative diseas...
SummaryNeonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of th...
The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells...
The most challenging aspect of secondary progressive multiple sclerosis (SPMS) is the lack of effici...
© 2015 Dr. Yao Lulu XingRemyelination following demyelination of the central nervous system is media...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeut...
Induced pluripotent stem cell-derived neural precursor cells (iPS-NPCs) may represent the ideal auto...