The recognition of helix-distorting deoxyribonucleic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by the XPC-RAD23-CEN2 complex. Although it has been established that Rad23 homologs are essential to protect XPC from proteasomal degradation, it is unclear whether RAD23 proteins have a direct role in the recognition of DNA damage. In this paper, we show that the association of XPC with ultraviolet-induced lesions was impaired in the absence of RAD23 proteins. Furthermore, we show that RAD23 proteins rapidly dissociated from XPC upon binding to damaged DNA. Our data suggest that RAD23 proteins facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process.</p
Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an ext...
The RAD23 proteins are responsible for both the binding and repairing of DNA molecules. Since DNA re...
AbstractThe xeroderma pigmentosum group G (XPG) gene, encoding an essential element in nucleotide ex...
The recognition of helix-distorting deoxyribonucleic acid (DNA) lesions by the global genome nucleot...
DNA repair is critical for maintaining genomic integrity. Finding DNA lesions initiates the entire r...
Primary DNA damage sensing in mammalian global genome nucleotide excision repair (GG-NER) is perform...
Nucleotide Excision Repair (NER) is a major DNA repair mechanism after UV light exposure. Rad23 in c...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
Nucleotide excision repair (NER) removes many dif-ferent types of DNA lesions. Most NER proteins are...
SummaryThe xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA d...
The xeroderma pigmentosum syndrome complementation group C (XP-C) is due to a defect in the global g...
XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex re...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
DNA damage repair is crucial for maintaining genomic integrity. Finding DNA lesions initiates the en...
Xeroderma pigmentosum complementation group C gene (XPC) encodes a protein of 125 kDa which is prese...
Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an ext...
The RAD23 proteins are responsible for both the binding and repairing of DNA molecules. Since DNA re...
AbstractThe xeroderma pigmentosum group G (XPG) gene, encoding an essential element in nucleotide ex...
The recognition of helix-distorting deoxyribonucleic acid (DNA) lesions by the global genome nucleot...
DNA repair is critical for maintaining genomic integrity. Finding DNA lesions initiates the entire r...
Primary DNA damage sensing in mammalian global genome nucleotide excision repair (GG-NER) is perform...
Nucleotide Excision Repair (NER) is a major DNA repair mechanism after UV light exposure. Rad23 in c...
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesio...
Nucleotide excision repair (NER) removes many dif-ferent types of DNA lesions. Most NER proteins are...
SummaryThe xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA d...
The xeroderma pigmentosum syndrome complementation group C (XP-C) is due to a defect in the global g...
XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex re...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
DNA damage repair is crucial for maintaining genomic integrity. Finding DNA lesions initiates the en...
Xeroderma pigmentosum complementation group C gene (XPC) encodes a protein of 125 kDa which is prese...
Abstract Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an ext...
The RAD23 proteins are responsible for both the binding and repairing of DNA molecules. Since DNA re...
AbstractThe xeroderma pigmentosum group G (XPG) gene, encoding an essential element in nucleotide ex...