Family screening in inherited cardiac arrhythmias has been performed in The Netherlands since 1996, when diagnostic DNA testing in long QT syndrome (LOTS) and hypertrophic cardiomyopathy (HCM) became technically possible. In multidisciplinary outpatient academic clinics, an adjusted protocol for genetic counselling, originally derived from predictive testing in Huntington's disease, is being used. 1110 Individuals, including 842 relatives of index patients, were informed about their risks, and most were tested molecularly and/or clinically for carriership of the disease present in their family. Of 345 relatives who were referred for cardiologic follow-up, 189 are being treated, because of an increased risk of life-threatening arrhythmias. E...
Hypertrophic cardiomyopathy is a common autosomal dominant disease, associated with heart failure an...
Hereditary heart diseases are typically characterized by autosomal dominant inheritance and delayed ...
Introduction: In current practice, probands are asked to inform relatives about the possibility of p...
Family screening in inherited cardiac arrhythmias has been performed in The Netherlands since 1996, ...
This thesis narrates the clinical experience of 15 years of cardiogenetic counseling in the Netherla...
Background The possibilities in the molecular genetics of long QT syndrome (LQTS) and hypertrophic c...
Increasing numbers of individuals are being referred to cardiogenetics outpatient clinics with poten...
ObjectivesThe purpose of this study was to investigate the follow-up and treatment of the mutation-c...
The spectrum of inherited arrhythmogenic diseases (IADs) includes disorders without overt structural...
The underlying genetic etiologies for a group of conditions known as inherited cardiac disease are b...
Objectives: The purpose of this study was to investigate the follow-up and treatment of the mutation...
Inherited cardiac diseases comprise a wide and heterogeneous spectrum of diseases of the heart, incl...
AbstractInherited arrhythmias, such as cardiomyopathies and cardiac ion channelopathies, along with ...
Screening families with hypertrophic cardiomyopathy (HCM) presents a common clinical problem to prac...
Objective. This exploratory study serves to illustrate the psychological impact on an extended famil...
Hypertrophic cardiomyopathy is a common autosomal dominant disease, associated with heart failure an...
Hereditary heart diseases are typically characterized by autosomal dominant inheritance and delayed ...
Introduction: In current practice, probands are asked to inform relatives about the possibility of p...
Family screening in inherited cardiac arrhythmias has been performed in The Netherlands since 1996, ...
This thesis narrates the clinical experience of 15 years of cardiogenetic counseling in the Netherla...
Background The possibilities in the molecular genetics of long QT syndrome (LQTS) and hypertrophic c...
Increasing numbers of individuals are being referred to cardiogenetics outpatient clinics with poten...
ObjectivesThe purpose of this study was to investigate the follow-up and treatment of the mutation-c...
The spectrum of inherited arrhythmogenic diseases (IADs) includes disorders without overt structural...
The underlying genetic etiologies for a group of conditions known as inherited cardiac disease are b...
Objectives: The purpose of this study was to investigate the follow-up and treatment of the mutation...
Inherited cardiac diseases comprise a wide and heterogeneous spectrum of diseases of the heart, incl...
AbstractInherited arrhythmias, such as cardiomyopathies and cardiac ion channelopathies, along with ...
Screening families with hypertrophic cardiomyopathy (HCM) presents a common clinical problem to prac...
Objective. This exploratory study serves to illustrate the psychological impact on an extended famil...
Hypertrophic cardiomyopathy is a common autosomal dominant disease, associated with heart failure an...
Hereditary heart diseases are typically characterized by autosomal dominant inheritance and delayed ...
Introduction: In current practice, probands are asked to inform relatives about the possibility of p...