Add to ORKGDuring 12-week haloperidol treatment of rats, the cataleptic effect of an additional challenge dose becomes gradually weaker. We studied whether such a tolerance phenomenon is related to receptor supersensitivity-thus leaving more spare receptors - to a shift in affinity of the receptors towards agonist binding or to an attenuation of a postsynaptic response to dopamine (D-2-type) receptor blockade in the rat basal ganglia. Receptor occupancy was studied with the radioactive agonist [H-3]N-propylapomorphine (NPA) and antagonist [H-3]N-methylspiperone (MSPIP) to label free dopamine D-2 receptors in vivo. Fos protein served as an index of the postsynaptic response, which was histochemically quantified. This study does not support the concept ...
The effect of repeated s.c. administration of various neuroleptics (haloperidol, sulpiride and cis-f...
Systemic or intra-striatal acute administration of nitric oxide synthase (NOS) inhibitors causes cat...
There are several lines of investigation, both preclinical and clinical, that suggest antipsychotic ...
During 12-week haloperidol treatment of rats, the cataleptic effect of an additional challenge dose ...
Dopamine receptor-G protein coupling and dopamine D(2) receptor density were assessed in rats treate...
The effects of long-term treatment with haloperidol (2mg/kg/day) on dopamine receptors in the rat st...
Rationale Repeated haloperidol treatment in rodents results in a day-to-day intensification of catal...
Since long-term neuroleptic therapy is known to alter brain dopamisergic sensitivity, we tested the ...
Chronic ganglioside treatment (10 mg/kg, i.p.) using the molecular species withonly one neuroaminic ...
The effect of chronic neuroleptic treatment on the relationship between the blockade of dopamine (DA...
We investigated whether the acute effects of haloperidol and clozapine on Fos expression in the rat ...
OF all the side effects of drugs used to treat psychotic illness such as schizophrenia, chronic tard...
Rats treated continually and chronically with trifluoperazine (ca 3 mg/kg/day) for six months initia...
It is well established that chronic treatment with neuroleptic agents which selectively block dopami...
Long-term drug studies in animals using antiparkinsonian drugs (L-dopa and bromocriptine) and neurol...
The effect of repeated s.c. administration of various neuroleptics (haloperidol, sulpiride and cis-f...
Systemic or intra-striatal acute administration of nitric oxide synthase (NOS) inhibitors causes cat...
There are several lines of investigation, both preclinical and clinical, that suggest antipsychotic ...
During 12-week haloperidol treatment of rats, the cataleptic effect of an additional challenge dose ...
Dopamine receptor-G protein coupling and dopamine D(2) receptor density were assessed in rats treate...
The effects of long-term treatment with haloperidol (2mg/kg/day) on dopamine receptors in the rat st...
Rationale Repeated haloperidol treatment in rodents results in a day-to-day intensification of catal...
Since long-term neuroleptic therapy is known to alter brain dopamisergic sensitivity, we tested the ...
Chronic ganglioside treatment (10 mg/kg, i.p.) using the molecular species withonly one neuroaminic ...
The effect of chronic neuroleptic treatment on the relationship between the blockade of dopamine (DA...
We investigated whether the acute effects of haloperidol and clozapine on Fos expression in the rat ...
OF all the side effects of drugs used to treat psychotic illness such as schizophrenia, chronic tard...
Rats treated continually and chronically with trifluoperazine (ca 3 mg/kg/day) for six months initia...
It is well established that chronic treatment with neuroleptic agents which selectively block dopami...
Long-term drug studies in animals using antiparkinsonian drugs (L-dopa and bromocriptine) and neurol...
The effect of repeated s.c. administration of various neuroleptics (haloperidol, sulpiride and cis-f...
Systemic or intra-striatal acute administration of nitric oxide synthase (NOS) inhibitors causes cat...
There are several lines of investigation, both preclinical and clinical, that suggest antipsychotic ...