Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd-2(dba)(3)/XPhos as the catalyst allows for the preparation of biaryl and heterobiagl compounds In high yields under mild conditions (room temperature to 40 degrees C) with short reaction times.