The Criteria of Diagnostic Pulmonary Tuberculosis Activity in Patients Working in Hazardous Working Conditions.

The article presents the analysis of clinical examination data of 76 patients with tuberculosis: 51 patients (1 group) who worked in hazardous conditions and 25 patients (2 group) who had no contact with hazardous factors. Changes in hematological parameters in patients have been analyzed and a new method for diagnosis of specific tuberculosis activity (SKAT) has been proposed. It was found that in patients under adverse conditions of production (group 1) pulmonary tuberculosis was detected 1,7 times (p<0,05) more often at the age of 40 years and older, unlike the second group, in which the disease was diagnosed 2,9 times more often (p<0,05) at the age of 21-30 years. In patients of the first group Mycobacteria tuberculosis were detected 1,4 times more often (p<0,05) as well. In patients with pulmonary tuberculosis, there were similar changes in hematological parameters (increasing number of leukocytes, eosinophils and erythrocyte sedi­mentation rate), which is characteristic for granulomatous inflammation. A new method for the diagnosis of tuber­cu­losis specific activity (SKAT) allows to determine the severity of tuberculosis activity and severity of the disease course