Endoplasmic Reticulum (ER) is an organelle that is vital for cell growth and maintenance of homeostasis. Recent studies have reported that numerous human diseases, including cancer, are strictly connected to disruption of ER homeostasis. In order to counteract adverse intracellular conditions, cancer cells induce protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-dependent, pro-adaptive unfolded protein response (UPR) signaling branches. If ER stress is severe or prolonged, pro-adaptive signaling networks are insufficient, resulting in apoptotic cell death of cancer cells. The main aim: of the study was to evaluate the biological activity of a small-molecule PERK inhibitor GSK2606414 in two cancer cell lines - human neuroblasto...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...
The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of protei...
Although there have been advances in our understanding of carcinogenesis and development of new trea...
Abstract Background Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic ...
The unfolded protein response (UPR) is an evolutionarily conserved stress response to intra- and ext...
International audienceTumor cells are often exposed to intrinsic and external factors that alter pro...
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of the main c...
Cancer is the second most frequent cause of death worldwide. It is considered to be one of the most ...
Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of endoge...
Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein...
Exploiting vulnerabilities in the intracellular signalling pathways of tumor cells is a key strategy...
BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfo...
Cancers cells have the ability to develop chemotherapy resistance, which is a persistent problem dur...
Unfolded protein response (UPR) is an adaptive response which is used for re-establishing protein ho...
Artículo de publicación ISIStress induced by the accumulation of unfolded proteins in the endoplasmi...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...
The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of protei...
Although there have been advances in our understanding of carcinogenesis and development of new trea...
Abstract Background Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic ...
The unfolded protein response (UPR) is an evolutionarily conserved stress response to intra- and ext...
International audienceTumor cells are often exposed to intrinsic and external factors that alter pro...
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of the main c...
Cancer is the second most frequent cause of death worldwide. It is considered to be one of the most ...
Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of endoge...
Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein...
Exploiting vulnerabilities in the intracellular signalling pathways of tumor cells is a key strategy...
BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfo...
Cancers cells have the ability to develop chemotherapy resistance, which is a persistent problem dur...
Unfolded protein response (UPR) is an adaptive response which is used for re-establishing protein ho...
Artículo de publicación ISIStress induced by the accumulation of unfolded proteins in the endoplasmi...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...
The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of protei...
Although there have been advances in our understanding of carcinogenesis and development of new trea...