The aim of this study was to analyse the correlation between HPV16 E6 variants and the physical status of viral genome (integrated, mixed, episomal) among patients with cervical cancer (n=40) and low-grade squamous intraepithelial lesions - LSIL (n=40). The study was performed on 80 HPV16 positive samples. HPV16 E6 variants were identified using PCR and DNA sequencing. Nucleotide sequences of E6 were compared with the prototype sequence (EUR-350T). The physical state of HPV DNA was determined as the ratio of E2/E6 copy number per cell. Twelve different intratypic variants were identified as belonging to European (in 77 samples) and North-American 1 (in 3 samples) sublineages. The most prevalent non-synonymous variant was EUR-350G, which occ...
The E1 ORF is one of the most conserved regions in the human papillomavirus (HPV) genome. The comple...
Several studies indicate that molecular variants of HPV-16 have different geographic distribution an...
Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigat...
The aim of this study was to identify sequence variants in the HPV 16 E6 gene in Korean women and to...
Background and objective: Cervical cancer usually is caused by HPV 16. However, HPV 16 varies within...
Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infe...
Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infe...
High-risk human papillomaviruses (HPVs) are risk factors for the development of cervical cancer. HPV...
Objectives. Human papillomavirus type 16 is a causative factor for development of cervical cancer. T...
Background: Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered ...
Objectives. Human papillomavirus type 16 is a causative factor for development of cervical cancer. T...
Viral genetic diversity within infected cells or tissues, called viral quasispecies, has been mostly...
Human papillomavirus (HPV) 16 genome integration into the host chromosome is a crucial event during ...
Background: Factors that favour a small proportion of HPV16 infections to progress to cancer are sti...
Background and objective: Cervical cancer usually is caused by HPV 16. However, HPV 16 varies within...
The E1 ORF is one of the most conserved regions in the human papillomavirus (HPV) genome. The comple...
Several studies indicate that molecular variants of HPV-16 have different geographic distribution an...
Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigat...
The aim of this study was to identify sequence variants in the HPV 16 E6 gene in Korean women and to...
Background and objective: Cervical cancer usually is caused by HPV 16. However, HPV 16 varies within...
Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infe...
Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infe...
High-risk human papillomaviruses (HPVs) are risk factors for the development of cervical cancer. HPV...
Objectives. Human papillomavirus type 16 is a causative factor for development of cervical cancer. T...
Background: Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered ...
Objectives. Human papillomavirus type 16 is a causative factor for development of cervical cancer. T...
Viral genetic diversity within infected cells or tissues, called viral quasispecies, has been mostly...
Human papillomavirus (HPV) 16 genome integration into the host chromosome is a crucial event during ...
Background: Factors that favour a small proportion of HPV16 infections to progress to cancer are sti...
Background and objective: Cervical cancer usually is caused by HPV 16. However, HPV 16 varies within...
The E1 ORF is one of the most conserved regions in the human papillomavirus (HPV) genome. The comple...
Several studies indicate that molecular variants of HPV-16 have different geographic distribution an...
Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigat...