Padre Pio’s letters to his spiritual adviser Padre Benedetto from San Marco in Lamis provide a unique window into the spiritual life and struggle of the Saint. Into the spiritual life and struggle. Padre Pio suffered both body and spirit. In the Epistolario I he described his physical pains of different kind. He felt the natural pains caused by illness or supernatural i.e. demonic torments and of the Divine origin (transverbation, stigmata). Describing his sufferings during the “Dark Night of the Soul” he pointed out some reasons of his anxieties and temptations. In this paper, I didn`t give any theological or philosophical explanation of the nature of sufferings. I d’like only to sketch a specific itinerary of Father Pio`s spiritual life. ...