Background: Under conditions of digital transformation, the effective decision-making process should involve the usage of different mathematical models and methods, one of which is the transportation problem. The transportation problem, as the problem of resource allocation, is applicable in such domains as manufacturing, information technologies, etc. To get more precise solutions, the multi-index transportation problem can be applied, which allows taking into account several variables. Methods: This paper develops an approach for applying the genetic algorithm for solving four-index transportation problems. Results: The steps of the genetic algorithm for solving four-index transportation problems are outlined. The research has proved the ...