The role of decellularization in biometarials manufacturing from xenogeneic tissues

Biological heart valves have represented an important area of the tissue-derived biomaterials. Decellularization processes are considered to be useful for manufacturing of biodegradable scaffolds hich make it possible to create living and functioning tissues. These processes result in elimination of most disadvantages of GA-stabilized tissues. Acellular tissues may be obtained using various chemical, enzymatic and mechanical methods. Decellularization processes give the possibility of creating biomaterials for cell seeding which are not immunogenic, cytotoxic and calcifying