The article offers aqualimetric assessment of the innovation in regional economic systems, taking into account digitization. The study was based on the methodology of general scientific methods of cognition and special methods of scientific research in the field of the development of productive forces and regional economy. Namely, we used the dialectical method of scientific cognition to identify contradictions and interrelations of innovative development of the subjects of regional economic systems; analysis and synthesis to identify the mechanism for identifying and implementing priority areas of innovation in the regions; the grouping method for clustering regions according to the calculated values of the integrated index of innovation o...