Shigella ssp cause bacillary dysentery (shigellosis) which has high global morbidity in young children and the elderly. The virulence of Shigella relies upon a type III secretion system (T3SS) which injects host altering effector proteins into targeted intestinal cells. The Shigella T3SS contains two components, invasion plasmid antigen D (IpaD) and invasion plasmid antigen B (IpaB), that were previously identified as broadly protective antigens. When IpaD and IpaB were co-expressed to give the DB fusion (DBF) protein, vaccine efficacy was further improved. Biophysical characterization under various pH conditions showed that DBF is most stable at pH 7 and 8 and loses its conformational integrity at 48 and 50 °C respectively. Forced degradat...
Crystalline arrays of proteinaceous subunits forming surface layers (S-layers) are now recognized as...
This is the peer reviewed version of the following article: ChemMedChem. 2017 Sep 21; 12(18): 1534–1...
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of ...
Shigella ssp cause bacillary dysentery (shigellosis) which has high global morbidity in young childr...
Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidit...
Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidit...
Infectious diarrhea is an important public health problem and a major cause of morbidity all over th...
Shigellosis is an important disease in the developing world, where about 90 million people become in...
Shigellosis is an important disease in the developing world, where about 90 million people become in...
Diarrheal diseases are a major cause of morbidity and mortality worldwide. They are most prevalent i...
Shigella are bacteria that are responsible for millions of infections and hundreds of thousands of d...
Shigella are pathogenic bacteria which commonly infect human hosts through the fecal-oral route. As ...
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of ...
Like many Gram-negative pathogens, Shigella rely on a type three secretion system (T3SS) for injecti...
Shigellosis is one of the leading causes of diarrhea worldwide with more than 165 million cases annu...
Crystalline arrays of proteinaceous subunits forming surface layers (S-layers) are now recognized as...
This is the peer reviewed version of the following article: ChemMedChem. 2017 Sep 21; 12(18): 1534–1...
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of ...
Shigella ssp cause bacillary dysentery (shigellosis) which has high global morbidity in young childr...
Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidit...
Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidit...
Infectious diarrhea is an important public health problem and a major cause of morbidity all over th...
Shigellosis is an important disease in the developing world, where about 90 million people become in...
Shigellosis is an important disease in the developing world, where about 90 million people become in...
Diarrheal diseases are a major cause of morbidity and mortality worldwide. They are most prevalent i...
Shigella are bacteria that are responsible for millions of infections and hundreds of thousands of d...
Shigella are pathogenic bacteria which commonly infect human hosts through the fecal-oral route. As ...
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of ...
Like many Gram-negative pathogens, Shigella rely on a type three secretion system (T3SS) for injecti...
Shigellosis is one of the leading causes of diarrhea worldwide with more than 165 million cases annu...
Crystalline arrays of proteinaceous subunits forming surface layers (S-layers) are now recognized as...
This is the peer reviewed version of the following article: ChemMedChem. 2017 Sep 21; 12(18): 1534–1...
Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of ...