The ability of a cardiac cell to work hard and continuously depends on the energy-producing function of its mitochondria. Calcium is key to proper mitochondrial function—but only in the right amounts. Too much calcium leads to cell death; too little suppresses production of the fuel a cell needs to function. Research collaborators Shey-Shing Sheu, PhD, professor of medicine, and Gyorgy Csordas, MD, research associate professor of pathology, anatomy and cell biology, are studying the mechanisms by which cardiac mitochondria use calcium and other molecules. And they are shedding light on how dysfunction in those mechanisms contribute to ischemic heart disease, cardiac arrhythmias and heart failure. Currently, Drs. Sheu and Csordas are engaged...
Atrial Fibrillation is the most common sustained cardiac arrhythmia worldwide harming millions of pe...
Transient increases in intracellular calcium concentration activate and coordinate a wide variety of...
Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understa...
The heart consists of millions of cells, namely cardiomyocytes, which are highly organized in terms ...
The heart is an organ with high-energy demands in which the mitochondria are most abundant. They are...
Mitochondria are key players in energy production, critical activity for the smooth functioning of e...
Mitochondria are key players in energy production, critical activity for the smooth functioning of e...
Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondri...
Calcium homeostasis is essential for regulating a wide spectrum of biological processes. In the hear...
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of AT...
KEY POINTS: Calcium ions regulate mitochondrial ATP production and contractile activity and thus pla...
Calcium can be regulated by mitochondria and also plays a significant role in mitochondrial pathways...
Aims: Alterations in calcium homeostasis in the intracellular endo/sarcoplasmic reticulum (ER/SR) an...
Mitochondria are important generators of energy, providing ATP through oxidative phosphorylation. Ho...
AIM: Calcium ions play a pivotal role in matching energy supply and demand in cardiac muscle. Mitoch...
Atrial Fibrillation is the most common sustained cardiac arrhythmia worldwide harming millions of pe...
Transient increases in intracellular calcium concentration activate and coordinate a wide variety of...
Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understa...
The heart consists of millions of cells, namely cardiomyocytes, which are highly organized in terms ...
The heart is an organ with high-energy demands in which the mitochondria are most abundant. They are...
Mitochondria are key players in energy production, critical activity for the smooth functioning of e...
Mitochondria are key players in energy production, critical activity for the smooth functioning of e...
Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondri...
Calcium homeostasis is essential for regulating a wide spectrum of biological processes. In the hear...
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of AT...
KEY POINTS: Calcium ions regulate mitochondrial ATP production and contractile activity and thus pla...
Calcium can be regulated by mitochondria and also plays a significant role in mitochondrial pathways...
Aims: Alterations in calcium homeostasis in the intracellular endo/sarcoplasmic reticulum (ER/SR) an...
Mitochondria are important generators of energy, providing ATP through oxidative phosphorylation. Ho...
AIM: Calcium ions play a pivotal role in matching energy supply and demand in cardiac muscle. Mitoch...
Atrial Fibrillation is the most common sustained cardiac arrhythmia worldwide harming millions of pe...
Transient increases in intracellular calcium concentration activate and coordinate a wide variety of...
Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understa...