The structural evolution related to the uplift of the Andean Cordillera between 33 and 35ºS is well known in the eastern Argentinean flank of the belt, in which it has been developed an east vergent thrust system. In turn, deformation in the Chilean flank of the chain has not been very well constrained and several discrepancies exist in order to explain uplift and Central Depression development. This study shows that in the Andes of Central Chile, compressive deformation consisted in a tectonic inversion accommodating ca. 16 km shortening between 22 and 16 Ma. This shortening is much lesser than that accumulated in the eastern flank of the chain (1/5 of total shortening), in which more than 70 km of shortening has been accommodated between ...