The Seine River and its basin (70 000 km2, 500 m3/s mean annual discharge) are studied since 1989 by an interdisciplinary research programme (https://www.piren-seine.fr/). The river receives the effluents of about 17 M inhab (70% from Paris conurbation) and from industries. Intensive agriculture using agrochemicals is another cause of water quality alteration. Morphological alterations (such as channelization and reservoirs construction) were considerable. From the 1970s to the 1990s, the Seine water quality was very poor downstream of Paris: summer oxygen deficit, nutrient excess and eutrophication, severe contamination by metals, persistant organics and emergent pollutants, including plastic debris, all detrimental to aquatic life, as rev...