The Global Phosphorylation Landscape of SARS-CoV-2 Infection
- Bouhaddou, Mehdi
- Memon, Danish
- Meyer, Bjoern
- White, Kris M.
- Rezelj, Veronica V.
- Correa Marrero, Miguel
- Polacco, Benjamin J.
- Melnyk, James E.
- Ulferts, Svenja
- Kaake, Robyn M.
- Batra, Jyoti
- Richards, Alicia L.
- Stevenson, Erica
- Gordon, David E.
- Rojc, Ajda
- Obernier, Kirsten
- Fabius, Jacqueline M.
- Soucheray, Margaret
- Miorin, Lisa
- Moreno, Elena
- Koh, Cassandra
- Tran, Quang Dinh
- Hardy, Alexandra
- Robinot, Rémy
- Vallet, Thomas
- Nilsson-Payant, Benjamin E.
- Hernandez-Armenta, Claudia
- Dunham, Alistair
- Weigang, Sebastian
- Knerr, Julian
- Modak, Maya
- Quintero, Diego
- Zhou, Yuan
- Dugourd, Aurelien
- Valdeolivas, Alberto
- Patil, Trupti
- Li, Qiongyu
- Hüttenhain, Ruth
- Cakir, Merve
- Muralidharan, Monita
- Kim, Minkyu
- Jang, Gwendolyn
- Tutuncuoglu, Beril
- Hiatt, Joseph
- Guo, Jeffrey Z.
- Xu, Jiewei
- Bouhaddou, Sophia
- Mathy, Christopher J.P.
- Gaulton, Anna
- Manners, Emma J.
- Félix, Eloy
- Shi, Ying
- Goff, Marisa
- Lim, Jean K.
- Mcbride, Timothy
- O’neal, Michael C.
- Cai, Yiming
- Chang, Jason C.J.
- Broadhurst, David J.
- Klippsten, Saker
- de Wit, Emmie
- Leach, Andrew R.
- Kortemme, Tanja
- Shoichet, Brian
- Ott, Melanie
- Saez-Rodriguez, Julio
- Tenoever, Benjamin R.
- Mullins, R. Dyche
- Fischer, Elizabeth R.
- Kochs, Georg
- Grosse, Robert
- García-Sastre, Adolfo
- Vignuzzi, Marco
- Johnson, Jeffery R.
- Shokat, Kevan M.
- Swaney, Danielle L.
- Beltrao, Pedro
- Krogan, Nevan J.
DOIAbstract
International audienceThe causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Infection also stimulated a marked induction of CK2-containing filopodial protrusion...
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