Most proteins associate into multimeric complexes with specific architectures(1,2), which often have functional properties such as cooperative ligand binding or allosteric regulation(3). No detailed knowledge is available about how any multimer and its functions arose during evolution. Here we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport and exchange by cooperatively binding oxygen with moderate affinity. We show that modern haemoglobin evolved from an ancient monomer and characterize the historical 'missing link' through which the modern tetramer evolved-a noncooperative homod...
Human hemoglobin (Hb), which is an α2β2 tetramer and binds four O2 molecules, changes its O2-affinit...
SummaryThe origin and evolution of modern biochemistry remain a mystery despite advances in evolutio...
Using a new template based on an alignment of 145 nonvertebrate globins we examined several recently...
Most proteins associate into multimeric complexes with specific architectures1,2, which often have f...
Most proteins associate into multimeric complexes with specific architectures, which often have func...
Hemoglobin, a multi-subunit protein used for oxygen transport to peripheral tissues in animals, has ...
During vertebrate evolution, duplicated hemoglobin (Hb) genes diverged with respect to functional pr...
<div><p>Hemoglobin transports molecular oxygen from the lungs to all human tissues for cellular resp...
Hemoglobin transports molecular oxygen from the lungs to all human tissues for cellular respiration....
Natural selection often promotes evolutionary innovation by coopting preexisting genes for new funct...
<div><p>Background</p><p>The evolution of oxygenic photosynthesis during Precambrian times entailed ...
Proteins are dynamic molecular machines whose structure and function are modulated by environmental ...
Hemoglobins (Hb) from lamprey and hagfish are composed of monomeric components in the oxygenated sta...
It has been hypothesized that two successive rounds of whole-genome duplication (WGD) in the stem li...
<div><p>Human hemoglobin (Hb), which is an α<sub>2</sub>β<sub>2</sub> tetramer and binds four O<sub>...
Human hemoglobin (Hb), which is an α2β2 tetramer and binds four O2 molecules, changes its O2-affinit...
SummaryThe origin and evolution of modern biochemistry remain a mystery despite advances in evolutio...
Using a new template based on an alignment of 145 nonvertebrate globins we examined several recently...
Most proteins associate into multimeric complexes with specific architectures1,2, which often have f...
Most proteins associate into multimeric complexes with specific architectures, which often have func...
Hemoglobin, a multi-subunit protein used for oxygen transport to peripheral tissues in animals, has ...
During vertebrate evolution, duplicated hemoglobin (Hb) genes diverged with respect to functional pr...
<div><p>Hemoglobin transports molecular oxygen from the lungs to all human tissues for cellular resp...
Hemoglobin transports molecular oxygen from the lungs to all human tissues for cellular respiration....
Natural selection often promotes evolutionary innovation by coopting preexisting genes for new funct...
<div><p>Background</p><p>The evolution of oxygenic photosynthesis during Precambrian times entailed ...
Proteins are dynamic molecular machines whose structure and function are modulated by environmental ...
Hemoglobins (Hb) from lamprey and hagfish are composed of monomeric components in the oxygenated sta...
It has been hypothesized that two successive rounds of whole-genome duplication (WGD) in the stem li...
<div><p>Human hemoglobin (Hb), which is an α<sub>2</sub>β<sub>2</sub> tetramer and binds four O<sub>...
Human hemoglobin (Hb), which is an α2β2 tetramer and binds four O2 molecules, changes its O2-affinit...
SummaryThe origin and evolution of modern biochemistry remain a mystery despite advances in evolutio...
Using a new template based on an alignment of 145 nonvertebrate globins we examined several recently...