Regional iron accumulation and α-synuclein (α-syn) spreading pathology within the central nervous system are common pathological findings in Parkinson's disease (PD). Whereas iron is known to bind to α-syn, facilitating its aggregation and regulating α-syn expression, it remains unclear if and how iron also modulates α-syn spreading. To elucidate the influence of iron on the propagation of α-syn pathology, we investigated α-syn spreading after stereotactic injection of α-syn preformed fibrils (PFFs) into the striatum of mouse brains after neonatal brain iron enrichment. C57Bl/6J mouse pups received oral gavage with 60, 120, or 240 mg/kg carbonyl iron or vehicle between postnatal days 10 and 17. At 12 weeks of age, intrastriatal injections o...
The major neuropathologic feature of Parkinsons disease is the presence of widespread intracellular ...
Iron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis, ener...
Recent data suggest mechanistic links among perturbed iron homeostasis, oxidative stress, and misfol...
Regional iron accumulation and α‐synuclein (α‐syn) spreading pathology within the central nervous sy...
International audienceParkinson’s disease is the most common α-synucleinopathy, and increased levels...
Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains e...
Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains e...
A key pathological process in Parkinson's disease (PD) is the transneuronal spreading of α-synuclein...
Both alpha-synuclein aggregation and iron deposits are neuropathological hallmarks of Parkinson’s di...
BACKGROUND Abnormal alpha-synuclein and iron accumulation in the brain play an important role in ...
The present study was aimed to investigate neuropathological changes in AβPP/PS1 transgenic mice (Tg...
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. It is characterized b...
Both elevated iron and α-synuclein (α-syn) aggregates are neuropathological hallmarks of Parkinson's...
Elevated iron in the SNpc may play a key role in Parkinson's disease (PD) neurodegeneration since dr...
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximat...
The major neuropathologic feature of Parkinsons disease is the presence of widespread intracellular ...
Iron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis, ener...
Recent data suggest mechanistic links among perturbed iron homeostasis, oxidative stress, and misfol...
Regional iron accumulation and α‐synuclein (α‐syn) spreading pathology within the central nervous sy...
International audienceParkinson’s disease is the most common α-synucleinopathy, and increased levels...
Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains e...
Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains e...
A key pathological process in Parkinson's disease (PD) is the transneuronal spreading of α-synuclein...
Both alpha-synuclein aggregation and iron deposits are neuropathological hallmarks of Parkinson’s di...
BACKGROUND Abnormal alpha-synuclein and iron accumulation in the brain play an important role in ...
The present study was aimed to investigate neuropathological changes in AβPP/PS1 transgenic mice (Tg...
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. It is characterized b...
Both elevated iron and α-synuclein (α-syn) aggregates are neuropathological hallmarks of Parkinson's...
Elevated iron in the SNpc may play a key role in Parkinson's disease (PD) neurodegeneration since dr...
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximat...
The major neuropathologic feature of Parkinsons disease is the presence of widespread intracellular ...
Iron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis, ener...
Recent data suggest mechanistic links among perturbed iron homeostasis, oxidative stress, and misfol...