4-Methylumbelliferone as a potent and selective antitumor drug on a glioblastoma model
- Pibuel, Matías Arturo
- Díaz, Mariángeles
- Molinari, Yamila Azul
- Poodts, Daniela
- Silvestroff, Lucas
- Lompardía, Silvina Laura
- Franco, Paula Gabriela
- Hajos, Silvia Elvira
DOIAbstract
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported. We aim to evaluate the antitumor effect of 4MU alone or combined with temozolomide (TMZ) on a GBM cell line, its absence of toxicity on brain cells and its selectivity for tumor cells. The antitumor effect of 4MU alone or combined with TMZ was evaluated on GL26 cells by assessing the metabolic activity through the XTT assay, cell proliferation by BrdU incorporation assay, migration by the wound healing assay, cell death by fluorescein diacetate/propidium io...
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