Surveillance of microcephaly and selected brain anomalies in Argentina: Relationship with Zika virus and other congenital infections
- Tellechea, Ana Laura
- Luppo, Victoria
- Morales, Maria Alejandra
- Groisman, Boris
- Baricalla, Agustin Ariel
- Fabbri, Cintia
- Sinchi, Anabel
- Alonso, Alicia Maria
- Gonzalez, Cecilia
- Ledesma, Bibiana
- Masi, Patricia
- Silva, María
- Israilev, Adriana
- Rocha, Marcela
- Quaglia, Marcela
- Bidondo, Maria Paz
- Liascovich, Rosa
- Barbero, Pablo Miguel
DOIAbstract
Background: Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. Methods: Participants were enrolled between April 2016 and March 2017. Cases: newborns from the National Network of Congenital Abnormalities of Argentina (RENAC) with head circumference lower than the 3rd percentile according to gestational age and sex, or selected brain anomalies. Blood and urine samples from cases and their mothers were tested for ZIKV by real-time polymerase chain reaction (RT-PCR...
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