The topical nanodelivery of vismodegib enhances its skin penetration and performance in vitro while reducing its toxicity in vivo
- Calienni, Maria Natalia
- Maza Vega, Daniela
- Temprana, Carlos Facundo
- Izquierdo, María Cecilia
- Ybarra, David Emanuel
- Bernabeu, Ezequiel Adrian
- Moretton, Marcela Analía
- Alvira, Fernando Carlos
- Chiappetta, Diego Andrés
- Alonso, Silvia del Valle
- Prieto, Maria Jimena
- Martinetti Montanari, Jorge Anibal
DOIAbstract
Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the in vitro and in vivo toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical applic...
Add to ORKG