Add to ORKGDetoxification of methylglyoxal, a toxic by-product of central sugar metabolism, is a major issue for all forms of life. The glyoxalase pathway evolved to effectively convert methylglyoxal into D-lactate via a glutathione hemithioacetal intermediate. Recently, we have shown that the monomeric glyoxalase I from maize exhibits a symmetric fold with two cavities, potentially harboring two active sites, in analogy with homodimeric enzyme surrogates. Here we confirm that only one of the two cavities exhibits glyoxalase I activity and show that it adopts a tunnel-shaped structure upon substrate binding. Such conformational change gives rise to independent binding sites for glutathione and methylglyoxal in the same active site, with important impl...
Human glyoxalase I is a Zn(II)-dependent isomerase that catalyzes the conversion of methylglyoxal-gl...
Glyoxalase 2 is a β-lactamase fold-containing enzyme that appears to be involved with cellular chemi...
Abstract Methylglyoxal(MG) is a potent cytotoxin that is produced as a byproduct of various metaboli...
Detoxification of methylglyoxal, a toxic by-product of central sugar metabolism, is a major issue fo...
The glyoxalase system is ubiquitous among all forms of life owing to its central role in relieving t...
All biological cells produce methylglyoxal, a toxic 2-oxoaldehyde, as a by-product of primary metabo...
Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) w...
The glyoxalase system is the ubiquitous pathway for the detoxification of methylglyoxal (MG) in the ...
Glycolysis generates methylglyoxal (MGO) as an unavoidable, cytotoxic by-product in plant cells. MGO...
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of...
In most organisms, methylglyoxal (MG), a toxic metabolite by-product that causes diabetes in humans,...
Density functional theory has been used to study the mechanism and stereospecificity of the catalyti...
Reactive carbonyl species (RCS) such as methylglyoxal (MGO) and glyoxal (GO) are highly reactive, un...
Understanding enzymatic reactions with atomic resolution has proven in recent years to be of tremend...
Plant hormones play a central role in various physiological functions and in mediating defense respo...
Human glyoxalase I is a Zn(II)-dependent isomerase that catalyzes the conversion of methylglyoxal-gl...
Glyoxalase 2 is a β-lactamase fold-containing enzyme that appears to be involved with cellular chemi...
Abstract Methylglyoxal(MG) is a potent cytotoxin that is produced as a byproduct of various metaboli...
Detoxification of methylglyoxal, a toxic by-product of central sugar metabolism, is a major issue fo...
The glyoxalase system is ubiquitous among all forms of life owing to its central role in relieving t...
All biological cells produce methylglyoxal, a toxic 2-oxoaldehyde, as a by-product of primary metabo...
Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) w...
The glyoxalase system is the ubiquitous pathway for the detoxification of methylglyoxal (MG) in the ...
Glycolysis generates methylglyoxal (MGO) as an unavoidable, cytotoxic by-product in plant cells. MGO...
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of...
In most organisms, methylglyoxal (MG), a toxic metabolite by-product that causes diabetes in humans,...
Density functional theory has been used to study the mechanism and stereospecificity of the catalyti...
Reactive carbonyl species (RCS) such as methylglyoxal (MGO) and glyoxal (GO) are highly reactive, un...
Understanding enzymatic reactions with atomic resolution has proven in recent years to be of tremend...
Plant hormones play a central role in various physiological functions and in mediating defense respo...
Human glyoxalase I is a Zn(II)-dependent isomerase that catalyzes the conversion of methylglyoxal-gl...
Glyoxalase 2 is a β-lactamase fold-containing enzyme that appears to be involved with cellular chemi...
Abstract Methylglyoxal(MG) is a potent cytotoxin that is produced as a byproduct of various metaboli...