Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment
- Harman, María Florencia
- Ranocchia, Romina Paola
- Gorlino, Carolina Virginia
- Sánchez Vallecillo, María Fernanda
- Castell, Sofía Daiana
- Crespo, Maria Ines
- Maletto, Belkys Angélica
- Morón, Sergio Gabriel
- Pistoresi, Maria Cristina
DOIAbstract
As we age, the homeostatic function of many systems in the body, such as the immune function declines, which in turn contributes to augment susceptibility to disease. Here we describe that challenging aged mice with synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG-ODN) emulsified in incomplete Freund's adjuvant (IFA), (CpG-ODN+IFA) an inflammatory stimulus, led to the expansion of CD11b+Gr1+ myeloid cells with augmented expression of CD124 and CD31. These myeloid cells lasted longer in the spleen of aged mice than in their younger counterparts after CpG-ODN+IFA treatment and were capable of suppressing T cell proliferative response by arginase induction. Myeloid cells from aged CpG-ODN+IFAtreated mice pre...
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