Excitotoxic levels of released glutamate trigger a cascade of deleterious cellular events leading to delayed neuronal death. This phenomenon implies extensive dysregulation in the balance between network excitation and inhibition. Our hypothesis was that enhancing network inhibition should prevent excitotoxicity and provide neuroprotection. To test this notion, we used mouse organotypic spinal slice cultures and explored if excitotoxicity caused by the potent glutamate analogue kainate was blocked by pharmacological increase in GABA A receptor activity. To this end we monitored (with a biosensor)real-time glutamate release following 1 h kainate application and quantified neuronal survival 24 h later. Glutamate release evoked by kainate was ...
Excitotoxicity is thought to be a major mechanism in many human disease states such as ischemia, tra...
Current knowledge concerning the molecular mechanisms of the cellular response to excitotoxic insult...
SummaryGlutamate is the most abundant excitatory neurotransmitter in the brain, and distinct classes...
Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhi...
Excitotoxic neuronal death has been linked to neurological and neurodegenerative diseases. Several s...
Glutamate-induced excitotoxicity is a major contributor to motor neuron (MN) degeneration in disorde...
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss and sev...
Increasing experimental and clinical evidence suggests that abnormal glutamate transmission might p...
<div><p>Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ran...
AbstractBrain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Sp...
Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging fro...
Excitotoxicity due to hyperactivation of glutamate receptors is thought to underlie acute spinal inj...
Glutamate is the major excitatory neurotransmitter in the mammalian CNS. Excitotoxicity refers to th...
This thesis investigated the mechanisms of neuroprotection and neurotoxicity in rat and human centr...
UnrestrictedGlutamate is the major excitatory neurotransmitter in the mammalian central nervous syst...
Excitotoxicity is thought to be a major mechanism in many human disease states such as ischemia, tra...
Current knowledge concerning the molecular mechanisms of the cellular response to excitotoxic insult...
SummaryGlutamate is the most abundant excitatory neurotransmitter in the brain, and distinct classes...
Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhi...
Excitotoxic neuronal death has been linked to neurological and neurodegenerative diseases. Several s...
Glutamate-induced excitotoxicity is a major contributor to motor neuron (MN) degeneration in disorde...
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss and sev...
Increasing experimental and clinical evidence suggests that abnormal glutamate transmission might p...
<div><p>Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ran...
AbstractBrain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Sp...
Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging fro...
Excitotoxicity due to hyperactivation of glutamate receptors is thought to underlie acute spinal inj...
Glutamate is the major excitatory neurotransmitter in the mammalian CNS. Excitotoxicity refers to th...
This thesis investigated the mechanisms of neuroprotection and neurotoxicity in rat and human centr...
UnrestrictedGlutamate is the major excitatory neurotransmitter in the mammalian central nervous syst...
Excitotoxicity is thought to be a major mechanism in many human disease states such as ischemia, tra...
Current knowledge concerning the molecular mechanisms of the cellular response to excitotoxic insult...
SummaryGlutamate is the most abundant excitatory neurotransmitter in the brain, and distinct classes...