Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
- Bujan, Ariana
- Alonso, Silvia del Valle
- Chiaramoni, Nadia Silvia
DOIAbstract
In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture as NAC delivery systems, with a possible dose reduction but maintaining its effect.Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity.Lipids belonging to lung surfactant were added in different ratios to the formulations in order to maximize itspossible interaction with the lung tissue. Because of lipopolymer stability, the oral or nasal route could beappropriated. This formulation could efficiently transport NAC to exert its mucolytic activity and help in diseasessu...
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