In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
- Alet, Analía Inés
- Batista Da Silva, Marcus Vinícius
- Castellini, Horacio Virginio
- Alet, Nicolás Alberto
- Riquelme, Bibiana Doris
DOIAbstract
Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of propofol, remifentanil, and vecuronium. For this, an in vitro study was performed on red blood cell samples from healthy donors incubated with solutions of propofol (4 μg/mL whole blood), remifentanil (10 ng/mL plasma), and vecuronium (0.15 μg/mL plasma). Erythrocyte viscoelastic parameters were determined by octuplicate using a Reometro ´ Eritrocitario. Also, a Wilcoxon signed rank-test with Yates correction for continuity was performed to analyze t...
Add to ORKG