A review of multivariate calibration methods applied to biomedical analysis
- Escandar, Graciela Monica
- Damiani, Patricia Cecilia
- Goicoechea, Hector Casimiro
- Olivieri, Alejandro Cesar
DOIAbstract
The determination of the contents of therapeutic drugs, metabolites and other important biomedical analytes in biological samples is usually performed by using high-performance liquid chromatography (HPLC). Modern multivariate calibration methods constitute an attractive alternative, even when they are applied to intrinsically unselective spectroscopic or electrochemical signals. First-order (i.e., vectorized) data are conveniently analyzed with classical chemometric tools such as partial least-squares (PLS). Certain analytical problems require more sophisticated models, such as artificial neural networks (ANNs), which are especially able to cope with non-linearities in the data structure. Finally, models based on the acquisition and proces...
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