Auxiliary Subunits of the Voltage-Gated Calcium Channel

Ion channels are critical for homeostasis. A few of these ion channels interact with auxiliary subunits which can modify the channel\u27s activities. With advances in genome sequencing and other sciences, the discovery of many transport auxiliary subunits was made possible. The auxiliary subunits of the voltage-gated calcium channels are potential targets to block the entry of calcium ions into specific cells. Recent interests in the pharmacology of the calcium auxiliary subunits prompted a large amount of effort in better understanding the role of moving the calcium ions. We used the Basic Local Alignment Search Tool (BLAST) to find homologous structure for the known auxiliary subunits. In comparison to the previous studies in 2018 and 2006, each auxiliary subunit has a greater number of sequences. γ 2,3,4,5,7, and 8 subunits had 28,930 of sequences. For the alpha2delta, we had a hit up to 13,11 sequences on a single BLAST. Using the large number of sequences, we were able to compare the mutations based on alignments. The large number of sequences allowed for us to have a better idea of the evolution of the auxiliary subunits