The region that becomes the ventromedial nucleus of the hypothalamus (VMH) is surrounded by cells and fibers containing immunoreactive gamma-aminobutyric acid (GABA) by embryonic day 13 (E13), several days before the nucleus emerges in Nissl stains. As GABA plays many roles during neural development, we hypothesized that it influences VMH development, perhaps by providing boundary information for migrating neurons. To test this hypothesis we examined the VMH in embryonic mice in which the β3 subunit of the GABAA-receptor, a receptor subunit that is normally highly expressed in this nucleus, was disrupted by gene targeting. In β3 −/− embryos the VMH was significantly larger, and the distribution of cells containing immunoreactive estrogen re...
The cerebral cortex is essential for integration and processing of information that is required for ...
Fetal alcohol spectrum disorders (FASD) result in many developmental abnormalities, including sensat...
Although focal cortical malformations are considered neuronal migration disorders, their formation m...
γ-Aminobutyric acid (GABA) is a highly abundant neurotransmitter in the brain and the ligand for GAB...
γ-Aminobutyric acid (GABA) is a highly abundant neurotransmitter in the brain and the ligand for GAB...
Using in vitro autoradiography to measure binding of the γ-aminobutyric acidA (GABAA) receptor agoni...
<div><p>Neurons of the paraventricular nucleus of the hypothalamus (PVN) regulate the hypothalamic- ...
2012 Fall.Includes bibliographical references.The paraventricular nucleus of the hypothalamus (PVN) ...
During rodent corticogenesis, a sizeable subpopulation of g-aminobutyric acid (GABA)ergic interneuro...
<p>GABA<sub>B</sub> receptor antagonists caused cells in slices from female embryos, but not male em...
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous s...
The GABAA receptor is a pentameric ligand gated ion channel complex assembled from a family of at le...
International audienceParacrine GABA and glutamate acting, respectively, on GABAA and NMDA receptors...
During rodent corticogenesis, a sizeable subpopulation of g-aminobutyric acid (GABA)ergic interneuro...
Thalamic ventrobasal (VB) relay neurones express multiple GABA(A) receptor subtypes mediating phasic...
The cerebral cortex is essential for integration and processing of information that is required for ...
Fetal alcohol spectrum disorders (FASD) result in many developmental abnormalities, including sensat...
Although focal cortical malformations are considered neuronal migration disorders, their formation m...
γ-Aminobutyric acid (GABA) is a highly abundant neurotransmitter in the brain and the ligand for GAB...
γ-Aminobutyric acid (GABA) is a highly abundant neurotransmitter in the brain and the ligand for GAB...
Using in vitro autoradiography to measure binding of the γ-aminobutyric acidA (GABAA) receptor agoni...
<div><p>Neurons of the paraventricular nucleus of the hypothalamus (PVN) regulate the hypothalamic- ...
2012 Fall.Includes bibliographical references.The paraventricular nucleus of the hypothalamus (PVN) ...
During rodent corticogenesis, a sizeable subpopulation of g-aminobutyric acid (GABA)ergic interneuro...
<p>GABA<sub>B</sub> receptor antagonists caused cells in slices from female embryos, but not male em...
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous s...
The GABAA receptor is a pentameric ligand gated ion channel complex assembled from a family of at le...
International audienceParacrine GABA and glutamate acting, respectively, on GABAA and NMDA receptors...
During rodent corticogenesis, a sizeable subpopulation of g-aminobutyric acid (GABA)ergic interneuro...
Thalamic ventrobasal (VB) relay neurones express multiple GABA(A) receptor subtypes mediating phasic...
The cerebral cortex is essential for integration and processing of information that is required for ...
Fetal alcohol spectrum disorders (FASD) result in many developmental abnormalities, including sensat...
Although focal cortical malformations are considered neuronal migration disorders, their formation m...