Analytical model for managing hypotony after implantation surgery of a glaucoma drainage device

This article has been updated.The main aim of glaucoma treatment is to reduce the intraocular pressure (IOP). One of the most common surgical treatments of glaucoma is the implantation of a glaucoma drainage device to drain the aqueous humor from the anterior chamber to a filtration bleb, where the aqueous humor is absorbed. In some cases, the excess of drainage causes ocular hypotony, which constitutes a sight-threatening complication. To prevent hypotony after this intervention, surgeons frequently introduce a suture into the device tube, which increases the hydraulic resistance of the tube and, therefore, the IOP. This study aims to provide an analytical model to correct hypotony following implantation surgery of a glaucoma drainage device, which may help glaucoma surgeons decide on hypotony treatment. The results indicate that the IOP after implanting a cylindrical tube around 300 μm in diameter is essentially the same as that built up in the filtering bleb and can hardly be controlled by introducing a straight suture unless the suture diameter is slightly lower than that of the tube. On the contrary, when the tube diameter is smaller than, for example, 100 μm, significant reductions of the IOP can be obtained by introducing a thin suture into the tube.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Partial support from the Junta de Extremadura through Grant No. GR18175 (partially financed by FEDER funds) is gratefully acknowledged. The work has been funded by a research grant from the San Carlos Clinical Hospital, Health Research Institute (IdISSC), Madrid, Spain.peerReviewe