New Platinum Agents, Triplatin and Triplatin NC, Suppress Advanced Breast and Pancreatic Cancer

• Triplatin and Triplatin NC suppressed cell growth of both Breast Cancer and Pancreatic Cancer in a dose dependent manner in vitro. • Both Triplatin and TriplatinNC demonstrated growth suppression of the primary breast tumor. A single animal (in the TriplatinNCgroup) was sacrificed due to weight loss. • In the advanced ex vivo lung metastasis model our most striking results were observed, where the agents nearly prohibited lung metastasis from occurring. • In the pancreatic cancer peritoneal carcinomatosis model, Triplatin reduced total tumor burden. Mouse survival was significantlyenhanced by the Triplatin treatment group and no mouse developed weight loss more than 25% of body weight. • The new platinum compounds with less cytotoxicity and favorable pharmacokinetics warrant further investigation to determine their role in advanced metastatic breast cancer and pancreatic carcinomatosis